Modeling, Synthesis and Biological Activity of Novel Antifungal Agents (1)

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1819-24. doi: 10.1016/s0960-894x(98)00316-3.

Abstract

Homology modeling of candida lanosterol C-14 demethylase, synthesis and in vitro antifungal activities of cyclohexyl analogs of restricticin are described.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antifungal Agents* / chemical synthesis
  • Antifungal Agents* / chemistry
  • Antifungal Agents* / pharmacology
  • Aspergillus fumigatus / drug effects
  • Candida albicans / drug effects
  • Cryptococcus neoformans / drug effects
  • Cytochrome P-450 Enzyme Inhibitors
  • Microbial Sensitivity Tests
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Models, Chemical
  • Molecular Sequence Data
  • Oxidoreductases / antagonists & inhibitors
  • Rats
  • Sequence Homology, Amino Acid
  • Sterol 14-Demethylase

Substances

  • Antifungal Agents
  • Cytochrome P-450 Enzyme Inhibitors
  • Oxidoreductases
  • Sterol 14-Demethylase