[3H]LY341495, a highly potent, selective and novel radioligand for labeling Group II metabotropic glutamate receptors

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1919-22. doi: 10.1016/s0960-894x(98)00329-1.

Abstract

We report herein the synthesis and pharmacological characterization of a tritiated version of the potent and selective cyclopropyl amino acid LY341495 as a radioligand to label group II metabotropic glutamate receptors in rat brain homogenates.

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / pharmacology*
  • Animals
  • Excitatory Amino Acid Antagonists / chemistry
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Prosencephalon / drug effects
  • Prosencephalon / metabolism
  • Radioligand Assay
  • Rats
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Tritium
  • Xanthenes / chemistry
  • Xanthenes / pharmacology*

Substances

  • Amino Acids
  • Excitatory Amino Acid Antagonists
  • LY 341495
  • Receptors, Metabotropic Glutamate
  • Xanthenes
  • Tritium