Functional molecules based on polyazometals. (1). Artificial metalloproteinases prepared by conjugation of polyazometals with poly(allylamine)

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2751-6. doi: 10.1016/s0960-894x(98)00489-2.

Abstract

Polyazometals (PAMs) conjugated with poly(allylamine) manifested high catalytic activity in the hydrolytic cleavage of bovine serum albumin. Based on cleavage sites, the mechanism for the PAM-catalyzed peptide hydrolysis is suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allylamine / analogs & derivatives*
  • Allylamine / chemistry
  • Azo Compounds / chemistry*
  • Binding Sites
  • Catalysis
  • Kinetics
  • Metalloendopeptidases / chemical synthesis*
  • Metalloendopeptidases / metabolism*
  • Organometallic Compounds / chemistry*
  • Polymers / chemistry
  • Serum Albumin, Bovine / metabolism

Substances

  • Azo Compounds
  • Organometallic Compounds
  • Polymers
  • Serum Albumin, Bovine
  • Allylamine
  • Metalloendopeptidases