Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3165-70. doi: 10.1016/s0960-894x(98)00555-1.


In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.

MeSH terms

  • Arginine
  • Benzimidazoles / pharmacology*
  • Benzodiazepines / pharmacology*
  • Receptors, Vitronectin / antagonists & inhibitors*
  • Structure-Activity Relationship


  • Benzimidazoles
  • Receptors, Vitronectin
  • Benzodiazepines
  • Arginine