Resveratrol as a new type of DNA-cleaving agent

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3187-92. doi: 10.1016/s0960-894x(98)00585-x.


The first demonstration of DNA cleavage by resveratrol '3,5,4'-trihydroxy-trans-stilbene' is presented. Resveratrol mediated relaxation of pBR322 at micromolar concentrations in the presence of Cu2+. Evidence is provided that resveratrol is capable of binding to DNA, and that the Cu(2+)-dependent DNA damage is more likely caused by a copper-peroxide complex rather than by a freely diffusible oxygen species.

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Copper / pharmacology
  • DNA / drug effects*
  • DNA Damage*
  • Hydroxyl Radical
  • Resveratrol
  • Stilbenes / pharmacology*


  • Antineoplastic Agents, Phytogenic
  • Stilbenes
  • Hydroxyl Radical
  • Copper
  • DNA
  • Resveratrol