Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3207-10. doi: 10.1016/s0960-894x(98)00584-8.


5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / metabolism
  • Dimerization
  • NF-kappa B / metabolism*
  • Oligonucleotides / metabolism*
  • Uridine / analogs & derivatives*
  • Uridine / metabolism


  • 5-formyl-2'-O-methyluridine
  • NF-kappa B
  • Oligonucleotides
  • DNA
  • Uridine