Boron trifluoride etherate on silica-A modified Lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells

Arch Pharm Res. 1998 Jun;21(3):353-6. doi: 10.1007/BF02975301.

Abstract

Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Boranes
  • Cannabinoids / chemistry
  • Cannabinoids / isolation & purification
  • Cannabinoids / pharmacology*
  • Carcinoma / drug therapy*
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mouth Neoplasms / drug therapy*
  • Nitroblue Tetrazolium
  • Silicon Dioxide
  • Spectrophotometry, Infrared

Substances

  • Antineoplastic Agents, Phytogenic
  • Boranes
  • Cannabinoids
  • Nitroblue Tetrazolium
  • boron trifluoride etherate
  • Silicon Dioxide
  • cannabigerol