The -491 A/T polymorphism in the regulatory region of the apolipoprotein E gene and early-onset Alzheimer's disease

Neurosci Lett. 1998 Dec 18;258(2):65-8. doi: 10.1016/s0304-3940(98)00857-x.


The -491 polymorphism in the promoter region of the apolipoprotein E gene (APOE) has been suggested to be associated with increased risk for Alzheimer's disease (AD) independent of APOE status. We studied the association between the -491 polymorphism and risk for early-onset Alzheimer's disease in 99 Dutch and 78 Spanish patients. In patients with early-onset AD, we found no consistent relationship with a single allele of the -491 polymorphism. Linkage disequilibrium between the polymorphism and the APOE gene was found which most likely might explain the inconsistent findings.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Alleles
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / genetics*
  • Chromosomes, Human, Pair 19 / genetics
  • Gene Frequency
  • Genetic Linkage
  • Genetic Testing
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Middle Aged
  • Point Mutation*
  • Polymorphism, Genetic*
  • Regulatory Sequences, Nucleic Acid*


  • Apolipoproteins E