Hydralazine-induced lupus and vocal fold paralysis

J Laryngol Otol. 1998 Sep;112(9):875-7. doi: 10.1017/s0022215100141945.


Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder that can affect the upper airway. Hydralazine has been known to cause a lupus-like syndrome that can produce the clinical manifestations of SLE. We discuss a case of hydralazine-induced lupus, presenting with acute laryngeal oedema and right vocal fold paralysis. Cessation of hydralazine therapy resulted in reversal of paralysis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antihypertensive Agents / adverse effects*
  • Female
  • Humans
  • Hydralazine / adverse effects*
  • Lupus Erythematosus, Systemic / chemically induced*
  • Middle Aged
  • Vocal Cord Paralysis / chemically induced*


  • Antihypertensive Agents
  • Hydralazine