Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice

Cell Mol Neurobiol. 1998 Dec;18(6):609-20. doi: 10.1023/a:1020677701368.

Abstract

1. Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by its reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cerebral ischemia.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Brain / physiopathology*
  • Brain Ischemia / physiopathology*
  • Brain Ischemia / prevention & control
  • Brain Ischemia / therapy*
  • Cerebral Infarction / pathology
  • Cerebral Infarction / physiopathology
  • Cerebrovascular Circulation / physiology
  • Humans
  • Mice
  • Mice, Transgenic
  • Nitrates / metabolism
  • Nitric Oxide / physiology
  • Superoxide Dismutase / genetics
  • Superoxide Dismutase / metabolism*
  • Superoxides / metabolism

Substances

  • Nitrates
  • Superoxides
  • peroxynitric acid
  • Nitric Oxide
  • Superoxide Dismutase