cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12

Genomics. 1998 Dec 15;54(3):569-74. doi: 10.1006/geno.1998.5621.

Abstract

Phosphoinositide (PI) 3-kinases have been shown to have critical roles in signaling pathways that regulate proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. We have previously used reverse-transcription polymerase chain reaction methods to identify novel PI 3-kinase isoforms in normal human breast and in lymph nodes containing metastatic breast cancer. Here we report the cDNA cloning of a Class II PI 3-kinase found in normal breast tissue. This gene (PIK3C2G) encodes the third distinct protein of the human Class II PI 3-kinase family, PI3K-C2gamma. PIK3C2G was mapped to chromosome 12 at 12p12 by fluorescence in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Cloning, Molecular
  • Gene Expression
  • Humans
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Phosphatidylinositol 3-Kinases / genetics*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Sequence Homology, Amino Acid
  • Tissue Distribution

Substances

  • Phosphatidylinositol 3-Kinases

Associated data

  • GENBANK/AJ000008