Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex

Brain Res. 1999 Jan 16;816(1):220-4. doi: 10.1016/s0006-8993(98)01108-1.

Abstract

We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Amphetamine / pharmacology*
  • Animals
  • Dopamine / metabolism
  • Drug Synergism
  • Hippocampus / drug effects
  • Hippocampus / metabolism
  • Homovanillic Acid / metabolism
  • Hydroxyindoleacetic Acid / metabolism
  • Male
  • Motor Activity / drug effects*
  • Narcotic Antagonists / pharmacology
  • Neurotransmitter Agents / metabolism*
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / metabolism
  • Oligopeptides / pharmacology*
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / metabolism
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / metabolism
  • Substance-Related Disorders / physiopathology

Substances

  • Narcotic Antagonists
  • Neurotransmitter Agents
  • Oligopeptides
  • 3,4-Dihydroxyphenylacetic Acid
  • Serotonin
  • Hydroxyindoleacetic Acid
  • phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide
  • Amphetamine
  • Dopamine
  • Homovanillic Acid