Insulin-like growth factors and ovarian physiology

J Obstet Gynaecol Res. 1998 Oct;24(5):305-23. doi: 10.1111/j.1447-0756.1998.tb00103.x.

Abstract

Objective: To review the available information regarding the roles of insulin-like growth factor (IGF)-IGF binding protein (IGFBP) system in ovarian physiology.

Design: Studies that specifically relate to the roles of ovarian folliculogenesis, oocyte maturation, and ovulation were identified through the literature and Medline searches.

Results: Numerous actions of the IGFs have been demonstrated in the ovary, including an enhancement of cell proliferation, aromatase activity, and progesterone biosynthesis. The ovarian IGF system, comprised of IGF-I and IGF-II peptides, IGFBPs and IGF receptors, plays a significant role in the process of follicular development. In addition, IGF-I stimulates the meiotic maturation of follicle-enclosed oocytes in vitro via the IGF-I receptors. IGFBP-3 significantly inhibit gonadotropin-induced ovulation and oocyte maturation by neutralizing endogenously produced IGF-I. Thus, the intraovarian IGF-IGFBP system play a significant role in the processes of follicular development, oocyte maturation, and ovulation.

Conclusion: IGF-IGFBP systems have autocrine/paracrine regulatory actions in ovarian physiology. The disturbance of the IGF-IGFBP system in human ovaries may lead to an ovulation, disorders of androgen excess, and infertility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Proteins / physiology*
  • Insulin-Like Growth Factor I / physiology
  • Oocytes
  • Ovarian Follicle / physiology
  • Ovary / physiology*
  • Ovulation / physiology*
  • Somatomedins / physiology*

Substances

  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins
  • Insulin-Like Growth Factor I