Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1999 Jan 8;283(5399):212-4.
doi: 10.1126/science.283.5399.212.

Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans

Free article
Clinical Trial

Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans

J A Levine et al. Science. .
Free article


Humans show considerable interindividual variation in susceptibility to weight gain in response to overeating. The physiological basis of this variation was investigated by measuring changes in energy storage and expenditure in 16 nonobese volunteers who were fed 1000 kilocalories per day in excess of weight-maintenance requirements for 8 weeks. Two-thirds of the increases in total daily energy expenditure was due to increased nonexercise activity thermogenesis (NEAT), which is associated with fidgeting, maintenance of posture, and other physical activities of daily life. Changes in NEAT accounted for the 10-fold differences in fat storage that occurred and directly predicted resistance to fat gain with overfeeding (correlation coefficient = 0.77, probability < 0.001). These results suggest that as humans overeat, activation of NEAT dissipates excess energy to preserve leanness and that failure to activate NEAT may result in ready fat gain.

Comment in

  • Beyond sloth--physical activity and weight gain.
    Ravussin E, Danforth E Jr. Ravussin E, et al. Science. 1999 Jan 8;283(5399):184-5. doi: 10.1126/science.283.5399.184. Science. 1999. PMID: 9925477 No abstract available.
  • A fidgeter's calculation.
    Cooke R. Cooke R. Science. 1999 May 14;284(5417):1125-6. doi: 10.1126/science.284.5417.1123h. Science. 1999. PMID: 10366345 No abstract available.

Similar articles

See all similar articles

Cited by 198 articles

See all "Cited by" articles

Publication types

LinkOut - more resources