Chronic recurrent multifocal osteomyelitis--report of eight patients

Pediatr Surg Int. 1998 Dec;14(3):195-8. doi: 10.1007/s003830050485.


The authors undertook a retrospective review of the clinical records and radiologic findings of eight children with chronic, recurrent multifocal osteomyelitis (CRMO). This disease is a recognized clinicopathologic entity with typical radiographic findings, mostly in the metaphyses of the long bones. The diagnosis is one of exclusion without pathognomonic findings. The patients were treated with non-steroidal anti-inflammatory drugs. There was no evidence of altered bone growth or abnormal joint development. It is concluded that CRMO is a distinct clinical entity that is different from acute or subacute bacterial osteomyelitis. Recognition of this condition is important to avoid treatment with antibiotics and repeated operations.

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Child
  • Child, Preschool
  • Chronic Disease
  • Diagnosis, Differential
  • Female
  • Humans
  • Male
  • Osteomyelitis* / diagnosis
  • Osteomyelitis* / diagnostic imaging
  • Osteomyelitis* / drug therapy
  • Radiography
  • Recurrence
  • Retrospective Studies


  • Anti-Inflammatory Agents, Non-Steroidal