Abstract
CNS activity of swertiamarin, a secoiridoid glucoside from Swertia chirata, was evaluated. An apparent anomaly, associated with the unanticipated finding that the alcoholic extracts (excluding mangiferin) of S. chirata significantly reversed the mangiferin-induced CNS-stimulating effects in albino mice and rats, was resolved. The results indicate that swertiamarin and mangiferin antagonize each other in vivo and thereby reverse their CNS effects.
MeSH terms
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Amphetamine / toxicity
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Animals
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Anticonvulsants
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Behavior, Animal / drug effects
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Central Nervous System / drug effects*
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Depression, Chemical
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Drug Interactions
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Glucosides / antagonists & inhibitors
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Glucosides / pharmacology*
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Glycosides / pharmacology*
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Hexobarbital / pharmacology
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Iridoid Glucosides
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Mice
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Morphine / pharmacology
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Motor Skills / drug effects
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Phenytoin / pharmacology
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Plant Extracts / pharmacology*
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Plants, Medicinal / analysis*
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Pyrans / pharmacology*
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Pyrones / pharmacology*
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Rats
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Sleep / drug effects
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Xanthenes / antagonists & inhibitors
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Xanthones
Substances
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Anticonvulsants
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Glucosides
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Glycosides
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Iridoid Glucosides
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Plant Extracts
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Pyrans
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Pyrones
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Xanthenes
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Xanthones
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mangiferin
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swertiamarin
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Phenytoin
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Morphine
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Hexobarbital
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Amphetamine