Linker histones: paradigm lost but questions remain

FEBS Lett. 1998 Dec 18;441(2):161-4. doi: 10.1016/s0014-5793(98)01512-9.


Linker histones (LH) represent a diverse family of proteins that bind to nucleosomes and bring them together to form a 30-nm chromatin fiber. Although the structure of the globular domain of linker histones H1 and H5 has been solved, the details of its interaction with the nucleosome are not understood in full. Recent data on the location of LH in nucleosome are discussed here.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Binding Sites
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism
  • Histones / chemistry
  • Histones / metabolism*
  • Models, Molecular
  • Protein Conformation


  • DNA-Binding Proteins
  • Histones