EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family

FEBS Lett. 1998 Dec 18;441(2):181-5. doi: 10.1016/s0014-5793(98)01541-5.


The two cytoskeletal proteins VASP and WASP and the protein Homer share a conserved domain, currently designated the WHI domain (WASP homology domain 1) or EVH1 domain (ENA/VASP homology domain 1), which could play an important role in various cellular events such as transport, folding of proteins, and signal transduction. We report here additional occurrences of this domain in Ran-binding proteins of the RanBP1 family and various others proteins, or putative proteins of eukaryotic organisms, suggesting that the EVH1/WH1 domain may be more widely used than originally thought.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules / chemistry*
  • GTP-Binding Proteins / chemistry*
  • Humans
  • Microfilament Proteins
  • Molecular Sequence Data
  • Nuclear Proteins / chemistry*
  • Phosphoproteins / chemistry*
  • Proteins / chemistry*
  • Sequence Homology, Amino Acid
  • Wiskott-Aldrich Syndrome Protein
  • ran GTP-Binding Protein*


  • Cell Adhesion Molecules
  • Microfilament Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Proteins
  • WAS protein, human
  • Wiskott-Aldrich Syndrome Protein
  • ran-binding protein 1
  • vasodilator-stimulated phosphoprotein
  • GTP-Binding Proteins
  • ran GTP-Binding Protein