Multiple intracranial hemorrhages at the time of a transiently prolonged activated partial thromboplastin time in an infant with congenital factor VII deficiency

Haemostasis. 1998 Jan-Feb;28(1):14-6. doi: 10.1159/000022378.


Factor VII (FVII) deficiency is a rare autosomal recessive hereditary disorder characterized by a normal partial thromboplastin time and a prolonged prothrombin time. For definitive diagnosis, the specific FVII level should be investigated. We report on a 7-month-old boy with congenital FVII deficiency suffering from convulsions and intracerebral hemorrhage. Hematologic tests revealed prolonged prothrombin time associated with a decreased FVII level of 1.7%. Computerized tomography of the brain revealed multifocal hemorrhagic lesions. To our knowledge, multifocal intracranial hemorrhages at the time of a transiently prolonged partial thromboplastin time of unknown origin in a child with congenital FVII deficiency of about 2% has not been reported so far.

Publication types

  • Case Reports

MeSH terms

  • Cerebral Hemorrhage / blood
  • Cerebral Hemorrhage / etiology*
  • Factor VII Deficiency / blood*
  • Factor VII Deficiency / congenital
  • Factor VII Deficiency / genetics*
  • Humans
  • Infant
  • Male
  • Partial Thromboplastin Time*
  • Time Factors