Increase in memory (CD4+CD29+ and CD4+CD45RO+) T and naive (CD4+CD45RA+) T-cell subpopulations in smokers

Arch Environ Health. Nov-Dec 1998;53(6):378-83. doi: 10.1080/00039899809605724.

Abstract

To examine the effects of smoking on lymphocyte subpopulations, we measured the following cell subpopulations: CD4+ T-cell subpopulations (i.e., CD4+CD29+, CD4+ CD45RO+, and CD4+CD45RA+ cells); CD8+ T-cell subpopulations (i.e., CD8+CD11a+ and CD8+CD11b+ cells); and natural killer cell subpopulations (i.e., CD16+CD57-, CD16+CD57+, and CD16-CD57+ cells). We measured these subpopulations, together with total CD4+ T, total CD8+ T, total CD3+ T, B (CD19+), and total lymphocytes, in 10 male heavy smokers, 38 male light-to-moderate smokers, and 33 male nonsmokers. The mean ages were 30 y, 31 y, and 32 y, respectively, and ages did not vary significantly among the smokers. CD4+CD29+ and CD4+CD45RO+ (memory T) cells in heavy smokers were significantly more numerous than those in light-to-moderate smokers and nonsmokers. Also, these memory T-cell subpopulations were significantly more numerous in light-to-moderate smokers than in nonsmokers. The number of CD4+CD45RA+ (naive T) cells was significantly larger in heavy smokers than nonsmokers; numbers of CD4+CD45RO+ T and CD4+CD29+ T cells (memory T cells) were significantly correlated with daily cigarette consumption. Numbers of CD3+ T, CD4+ T, CD19+ B, and total lymphocytes in heavy smokers were significantly larger than in nonsmokers. There were significantly more CD3+ T, CD4+ T, and total lymphocytes in light-to-moderate smokers than in nonsmokers. The numbers of CD4+ T lymphocytes in heavy smokers were significantly larger than in light-to-moderate smokers. Perhaps CD4+ T cell subpopulations, especially memory T cells, are most susceptible to the effects of smoking on lymphocyte subpopulations.

MeSH terms

  • Adult
  • Antigens, CD19 / blood
  • CD3 Complex / blood
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology*
  • CD57 Antigens / blood
  • CD8-Positive T-Lymphocytes / immunology*
  • Case-Control Studies
  • Humans
  • Integrin beta1 / blood
  • Killer Cells, Natural / immunology*
  • Leukocyte Common Antigens / blood
  • Lymphocyte Count
  • Lymphocyte Function-Associated Antigen-1 / blood
  • Macrophage-1 Antigen / blood
  • Male
  • Receptors, IgG / blood
  • Smoking / blood
  • Smoking / immunology*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Antigens, CD19
  • CD3 Complex
  • CD57 Antigens
  • Integrin beta1
  • Lymphocyte Function-Associated Antigen-1
  • Macrophage-1 Antigen
  • Receptors, IgG
  • Leukocyte Common Antigens