Randomized controlled trial of pulse/synchronization cyclophosphamide/apheresis for proliferative lupus nephritis

J Clin Apher. 1998;13(4):163-6. doi: 10.1002/(sici)1098-1101(1998)13:4<163::aid-jca4>3.0.co;2-1.


Objective: To assess the efficacy of pulse/synchronization cyclophosphamide/apheresis in patients with proliferative lupus nephritis.

Methods: Eighteen patients with Class III or IV renal biopsies and chronicity indices <6 were prospectively randomized to receive 6 courses of parenteral cyclophosphamide over 8 months along with prednisone. Nine of these patients also received 3 daily plasmaphereses prior to each of the 6 courses of cyclophosphamide. Assessments compiled at 6 and 24 months included serum creatinine, albumin, anti DNA, 24-hour urine protein, and C3 complement along with SLAM scores.

Results: Two out of nine patients in each group evolved end stage renal disease and 3/9 patients in each group went into a renal remission at 24 months. Serum albumin, C3 complement, and SLAM scores improved in both groups, and anti-DNA improved in the pulse/synchronization patients (P < 0.025). No intergroup comparisons were significant.

Conclusion: The addition of pulse/synchronization apheresis to cyclophosphamide therapy does not improve the course of patients with proliferative lupus nephritis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Component Removal / methods*
  • Cell Division / drug effects
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage*
  • Drug Administration Schedule
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Lupus Nephritis / therapy*


  • Immunosuppressive Agents
  • Cyclophosphamide