Diurnal variation of nasal protein concentration

Acta Otolaryngol. Sep-Oct 1976;82(3-4):219-21. doi: 10.3109/00016487609120888.


In normal subjects a marked diurnal variation was disclosed in the concentrations of immunoglobulin G (IgG), IgA and albumin in nasal secretion, the night values being 4.5-5.5 times higher than those during the day. It is suggested that this is due to changing secretory activity of the nasal glands.

MeSH terms

  • Albumins / metabolism*
  • Circadian Rhythm
  • Humans
  • Immunoglobulin A* / analysis
  • Immunoglobulin A, Secretory* / analysis
  • Immunoglobulin G / metabolism*
  • Nasal Mucosa / immunology*
  • Nasal Mucosa / metabolism


  • Albumins
  • Immunoglobulin A
  • Immunoglobulin A, Secretory
  • Immunoglobulin G