Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa

Prostaglandins Leukot Essent Fatty Acids. 1998 Nov;59(5):313-6. doi: 10.1016/s0952-3278(98)90079-5.


Recent studies indicate that expression of mitogen-inducible cyclooxygenase-2 (COX-2) occurs in gastrointestinal tumors. We investigated the effects of Helicobacter pylori (H. pylori) infection, a class I carcinogen for the human stomach, on gastric COX-2 expression using immunohistochemistry. Human subjects without macroscopic lesions, as determined by endoscopic screening, were biopsied for H. pylori infection. The biopsy samples were immunohistochemically examined for COX-2 expression. COX-2 was expressed in gastric epithelia and subepithelial inflammatory cells in all H. pylori-infected subjects. There was no expression of COX-2 in the gastric mucosa of H. pylori-negative subjects. COX-2 expression has been reported in gastrointestinal carcinomas, gastrointestinal cancer cell-lines, and in the gut after carcinogenic treatment. The present study demonstrates that H. pylori infection leads to gastric mucosal expression of COX-2, indicating that the enzyme is involved in H. pylori-related gastric pathology in humans.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cyclooxygenase 2
  • Epithelial Cells / enzymology
  • Epithelial Cells / pathology
  • Female
  • Gastric Mucosa / enzymology*
  • Gastric Mucosa / microbiology*
  • Gastric Mucosa / pathology
  • Helicobacter Infections / enzymology*
  • Helicobacter pylori*
  • Humans
  • Isoenzymes / immunology
  • Isoenzymes / metabolism*
  • Male
  • Membrane Proteins
  • Middle Aged
  • Prostaglandin-Endoperoxide Synthases / immunology
  • Prostaglandin-Endoperoxide Synthases / metabolism*


  • Isoenzymes
  • Membrane Proteins
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • Prostaglandin-Endoperoxide Synthases