Multiple uterine leiomyomas: cytogenetic analysis

Gynecol Oncol. 1999 Jan;72(1):71-5. doi: 10.1006/gyno.1998.5222.


Six uterine leiomyomas were studied cytogenetically. The material comprised two uterine myomas from one patient and four tumors from a second patient. In all cases the modal number was 46. The clonal numerical alterations were monosomies involving chromosomes X, 6, 8, 13, 19, and trisomy of 12. The only clonal structural alteration was der(11)t(10;11)(q11;q24). Although two monosomies (X and 8) were shared by two of four leiomyomas from the same uterus, the results suggested that each leiomyoma was the product of a separate clonal development.

MeSH terms

  • Female
  • Humans
  • Karyotyping
  • Leiomyoma / genetics*
  • Leiomyoma / pathology*
  • Middle Aged
  • Uterine Neoplasms / genetics*
  • Uterine Neoplasms / pathology*