Abstract
Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily D, Member 1
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ATP-Binding Cassette Transporters / genetics
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Animals
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Chromosome Mapping
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DNA-Binding Proteins / genetics
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Dosage Compensation, Genetic*
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Evolution, Molecular*
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Gene Expression Regulation, Developmental
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Genetic Linkage
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Humans
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Kruppel-Like Transcription Factors
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Membrane Proteins / genetics
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Sex Chromosomes / genetics*
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Transcription Factors
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X Chromosome / genetics
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Y Chromosome / genetics
Substances
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ABCD1 protein, human
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ATP Binding Cassette Transporter, Subfamily D, Member 1
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ATP-Binding Cassette Transporters
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DNA-Binding Proteins
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Kruppel-Like Transcription Factors
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Membrane Proteins
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Transcription Factors
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ZFY protein, human
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zinc finger protein, X-linked