Sex chromosomes: evolving dosage compensation

Curr Biol. 1998 Dec;8(25):R931-3. doi: 10.1016/s0960-9822(98)00013-x.

Abstract

Dosage compensation of some X-linked genes varies among mammals. Inactivation of an X-linked copy of a gene in females appears to correlate with lack of an active homologue on the Y chromosome, implying that dosage compensation evolves in response to the loss of function of genes on the Y.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily D, Member 1
  • ATP-Binding Cassette Transporters / genetics
  • Animals
  • Chromosome Mapping
  • DNA-Binding Proteins / genetics
  • Dosage Compensation, Genetic*
  • Evolution, Molecular*
  • Gene Expression Regulation, Developmental
  • Genetic Linkage
  • Humans
  • Kruppel-Like Transcription Factors
  • Membrane Proteins / genetics
  • Sex Chromosomes / genetics*
  • Transcription Factors
  • X Chromosome / genetics
  • Y Chromosome / genetics

Substances

  • ABCD1 protein, human
  • ATP Binding Cassette Transporter, Subfamily D, Member 1
  • ATP-Binding Cassette Transporters
  • DNA-Binding Proteins
  • Kruppel-Like Transcription Factors
  • Membrane Proteins
  • Transcription Factors
  • ZFY protein, human
  • zinc finger protein, X-linked