DNA segregation: putting chromosomes in their place

Curr Biol. 1998 Dec 17-31;8(25):R925-7. doi: 10.1016/s0960-9822(98)00011-6.


Recent studies provide evidence that bacterial chromosomes are replicated by an enzyme factory, the replisome, located at a fixed position at the center of the cell; the fixed replisome could be a major factor in determining chromosome order in the cell, and may provide the force that drives chromosome segregation.

MeSH terms

  • Bacteria / genetics
  • Cell Division / genetics
  • Chromosomes, Bacterial / physiology*
  • DNA Replication / physiology*
  • DNA, Bacterial / metabolism*
  • Microscopy, Fluorescence


  • DNA, Bacterial