Effects of fluoxetine administration on mu-opoid receptor immunostaining in the rat forebrain

Brain Res. 1999 Jan 30;817(1-2):236-40. doi: 10.1016/s0006-8993(98)01256-6.


Fluoxetine is a selective serotonin reuptake inhibitor. Analysis of mu-opioid receptor immunostaining after chronic fluoxetine administration in rats revealed an increase in the density of cells expressing mu-opioid receptors in the caudatus-putamen, the dentate gyrus, the lateral septum and the frontal, parietal and piriform cortices. These data suggest that mu-opioid receptor expression in the rat forebrain is altered by in vivo chronic fluoxetine treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fluoxetine / pharmacology*
  • Immunohistochemistry
  • Male
  • Prosencephalon / chemistry
  • Prosencephalon / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Opioid, mu / analysis*
  • Serotonin Uptake Inhibitors / pharmacology*


  • Receptors, Opioid, mu
  • Serotonin Uptake Inhibitors
  • Fluoxetine