Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants

Biochim Biophys Acta. 1999 Jan 8;1415(2):369-74. doi: 10.1016/s0005-2736(98)00233-8.

Abstract

In humans, at least six members of the multidrug resistance-associated protein (MRP) family are thought to exist. Here we report the molecular cloning of two splice variants of MRP3 from human liver. In addition, MRP3 genomic organization including the 5'-flanking region and a major portion of the MRP3 intron-exon organization are identified and characterized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / genetics*
  • Alternative Splicing*
  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Drug Resistance, Multiple
  • Humans
  • Liver / metabolism*
  • Molecular Sequence Data
  • Multidrug Resistance-Associated Proteins*

Substances

  • ATP-Binding Cassette Transporters
  • Multidrug Resistance-Associated Proteins
  • multidrug resistance-associated protein 3

Associated data

  • GENBANK/AF085690
  • GENBANK/AF085691
  • GENBANK/AF085692