The role of inherited thrombotic disorders in the etiology of Legg-Calvé-Perthes disease

J Pediatr Orthop. Jan-Feb 1999;19(1):82-3.


Inherited thrombophilia has been suggested as a cause of Legg-Calvé-Perthes disease in up to 75% of patients. This prevalence seems high compared to the prevalence of inherited thrombophilia in other thrombotic disorders (average, 30%). Therefore, we investigated 44 patients with Legg-Calvé-Perthes disease for antithrombin-III, protein-C, and protein-S deficiency and activated protein C (APC) resistance. Three (6.8%) of our patients were positive for APC resistance, and one patient (2.2%) showed deficiency of protein-C activity. Our results suggest that inherited thrombophilia is not associated with avascular necrosis of the femoral head (Legg-Calvé-Perthes disease).

MeSH terms

  • Activated Protein C Resistance / complications
  • Adolescent
  • Adult
  • Antithrombin III / analysis
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Legg-Calve-Perthes Disease / blood
  • Legg-Calve-Perthes Disease / etiology*
  • Male
  • Protein S Deficiency / complications
  • Thrombophilia / complications*


  • Antithrombin III