Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis

Amino Acids. 1998;15(4):389-92. doi: 10.1007/BF01320903.

Abstract

Papain-catalyzed regioselective cleavage of alpha-methyl ester in Z-DL-Asu(OMe)-OMe leads to Z-L-Asu(OMe)-OH and Z-D-Asu(OMe)-OMe. Subsequent saponifications yield Z-L-Asu-OH and Z-D-Asu-OH. The enzymatic alpha-ester hydrolysis was also achieved by subtilisin BPN' in organic solvent with low water content.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids, Dicarboxylic / analysis*
  • Caprylates*
  • Dicarboxylic Acids / chemistry*
  • Hydrolysis
  • Papain / chemistry
  • Subtilisins / chemistry

Substances

  • Amino Acids
  • Amino Acids, Dicarboxylic
  • Caprylates
  • Dicarboxylic Acids
  • 2-aminosuberic acid
  • suberic acid
  • Subtilisins
  • Papain