The HIV-1 Rev protein

Annu Rev Microbiol. 1998;52:491-532. doi: 10.1146/annurev.micro.52.1.491.

Abstract

The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.

Publication types

  • Review

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Carrier Proteins / analysis
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Cell Nucleus / metabolism
  • Gene Expression Regulation, Viral
  • Gene Products, rev / analysis
  • Gene Products, rev / genetics
  • Gene Products, rev / metabolism
  • Gene Products, rev / physiology*
  • HIV Infections / therapy
  • HIV-1 / chemistry*
  • Humans
  • Karyopherins*
  • Molecular Sequence Data
  • RNA, Messenger / metabolism
  • RNA, Viral / chemistry
  • RNA, Viral / metabolism
  • Receptors, Cytoplasmic and Nuclear*
  • Trans-Activators
  • rev Gene Products, Human Immunodeficiency Virus

Substances

  • Carrier Proteins
  • Gene Products, rev
  • Karyopherins
  • RNA, Messenger
  • RNA, Viral
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • exportin 1 protein
  • rev Gene Products, Human Immunodeficiency Virus