Best-Case Analyses of 4 Current Unconventional Therapies in OncologyBest-case analyses are - under certain circumstances - a useful method to decide on the tumor-specific efficacy of unconventional treatments, without performing formal clinical studies and with limited expenditure. As part of the activities of the 'Arbeitsgruppe Biologische Krebstherapie', sponsored by the 'Deutsche Krebshilfe', an analysis and second-opinion judgement (according to internationally accepted standards) of their 'best cases' was offered to 36 manufacturers and users of unconventional cancer drugs and methods, who in public propagated these as effective cancer therapies. Only few of the approached offerers were both willing to cooperate and able to provide significant documentation for such an analysis. Therefore, only four best-case analyses could be performed completely. The work-up of the available documentation was not very convincing in all four cases, especially when considering that a positive selection from hundreds or even thousands of applications had taken place. The results of the analyses did not reveal any well-founded evidence for a tumor-specific effectiveness of the corresponding applications. The discrepancy between the offerers and the working group's judgements results especially from the circumstance that the majority of the treatments were not performed on patients with advanced tumor disease without any other conventional therapies, but additionally to established therapies or as an adjuvant treatment protocol. Other reasons were the obvious misjudgement of findings, the assessment of unimportant or unsuitable parameters, the misinterpretation of the probably normal development as a treatment success or also documentation inappropriate for evaluation.