Growth factor receptor expression in human gastroenteropancreatic neuroendocrine tumours

Eur J Clin Invest. 1998 Dec;28(12):1038-49. doi: 10.1046/j.1365-2362.1998.00397.x.


Background: Human gastroenteropancreatic neuroendocrine tumours are functionally and biologically heterogeneous, but their exact growth factor receptor expression pattern, important for onco- and carcinogenesis, remains unknown.

Methods: This study searched for the mRNA expression pattern of six tyrosine- and serine/threonine kinase receptors [hepatocyte growth factor (HGFR), fibroblast growth factor (FGFR), epidermal growth factor (EGFR), insulin-like growth factor (IGF)-1R, transforming growth factor (TGF)-betaR1, TGF-betaR2] together with the five somatostatin receptors in human gastroenteropancreatic neuroendocrine tumours (gastrinomas, insulinomas, tumours with carcinoid syndrome, functionally inactive neuroendocrine tumours) using reverse transcriptase-polymerase chain reaction (RT-PCR).

Results: EGF receptor was expressed almost exclusively in gastrinomas. Among the four tumour subtypes, expression frequencies of the somatostatin receptors 1 and 5, HGF-, IGF-1-, TGF-betaR1, TGF-betaR2 and the EGF-receptor varied significantly.

Conclusions: In spite of the common cellular origin of these tumours, differences in growth factor receptor expression suggest the existence of different pathways during tumour subtype development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • ErbB Receptors / metabolism
  • Female
  • Gastrointestinal Neoplasms / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / metabolism*
  • Pancreatic Neoplasms / metabolism*
  • Proto-Oncogene Proteins c-met / metabolism
  • RNA, Messenger / metabolism
  • Receptors, Fibroblast Growth Factor / metabolism
  • Receptors, Growth Factor / metabolism*
  • Receptors, Somatostatin / metabolism
  • Receptors, Transforming Growth Factor beta / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sex Factors


  • RNA, Messenger
  • Receptors, Fibroblast Growth Factor
  • Receptors, Growth Factor
  • Receptors, Somatostatin
  • Receptors, Transforming Growth Factor beta
  • ErbB Receptors
  • Proto-Oncogene Proteins c-met