[Clinical relevance of lithium determination in RBC: results of a catamnestic study (author's transl)]

Arzneimittelforschung. 1976;26(6):1145-7.
[Article in German]


In 34 out-patients Li+- and K+-concentrations were determined in plasma and RBC during 15 months of clinical routine observations. Average frequency of check-ups was 9/patient. Psychopathological state and side effects were documented by the AMP-system. The mean intra-extracellular lithium concentration ratio (LiQ) was 34%. The ratio and the absolute lithium RBC concentration showed a wide intraindividual variability between 5 and 53%. Patients under 50 years old had the same absolute concentration values as the older ones but required a 50% higher average dose. Side effects such as tremor and thirst correlated well the intra-extracellular ratio. No difference was found between unipolar and bipolar depressions. LiQ was slightly reduced and KQ increased in patients with severe relapses or additional psychotropic medication.

Publication types

  • English Abstract

MeSH terms

  • Affective Symptoms / blood*
  • Age Factors
  • Animals
  • Bipolar Disorder / blood
  • Erythrocytes / analysis*
  • Female
  • Humans
  • Lithium / adverse effects
  • Lithium / blood*
  • Male
  • Potassium / blood
  • Rats
  • Recurrence


  • Lithium
  • Potassium