Chronological changes in brain MRI, SPECT, and EEG in neurosarcoidosis with stroke-like episodes

Psychiatry Clin Neurosci. 1998 Dec;52(6):629-33. doi: 10.1111/j.1440-1819.1998.tb02711.x.


Neurosarcoidosis with recurrent stroke-like episodes has been reported only rarely in the literature. We repeatedly measured brain magnetic resonance images (MRI), SPECT, and electroencephalograms (EEG) in a 32-year-old male patient with this condition. In the acute stage of the episodes, he showed semi-coma followed by severe dysphasia; left-frontal EEG delta wave activities and left-sided hyperperfusion SPECT were noted. Gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) MRI findings were aggravated diffusely in the convalescent stage of the disease rather than in the acute stage. The EEG and SPECT findings were clearly reflective of an early stage of acute encephalomeningitis caused by the neurosarcoidosis, and thus are more useful than MRI for evaluation of the acute inflammatory process in this condition.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Brain Diseases / diagnostic imaging
  • Brain Diseases / metabolism
  • Brain Diseases / physiopathology*
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / metabolism
  • Cerebrovascular Disorders / physiopathology*
  • Electroencephalography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Radiopharmaceuticals
  • Recurrence
  • Sarcoidosis / diagnostic imaging
  • Sarcoidosis / metabolism
  • Sarcoidosis / physiopathology*
  • Technetium Tc 99m Exametazime
  • Time Factors
  • Tomography, Emission-Computed, Single-Photon


  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime