Fetal hyperinsulinism in rhesus isoimmunization

Am J Obstet Gynecol. 1978 Jul 15;131(6):682-6. doi: 10.1016/0002-9378(78)90832-3.


Analyses of peritoneal ascitic fluid obtained prior to intrauterine transfusion show that some babies with severe rhesus isoimmunization develop raised insulin levels up to a month before delivery. The glucose content of fetal ascitic fluid is usually only about 10 mg. per 100 ml. less than the glucose content of maternal plasma and there is no evidence that this relation is influenced by the fetal or maternal insulin level. The electrolyte content of fetal ascitic fluid is very similar to that of maternal plasma, but fluid from babies with hyperinsulinism has an unusually high calcium content.

MeSH terms

  • Ascitic Fluid / metabolism
  • Electrolytes / metabolism
  • Erythroblastosis, Fetal / embryology*
  • Erythroblastosis, Fetal / metabolism
  • Female
  • Fetal Blood
  • Fetus / metabolism
  • Glucose / metabolism
  • Humans
  • Hyperinsulinism / diagnosis
  • Hyperinsulinism / embryology*
  • Hyperinsulinism / metabolism
  • Infant, Newborn
  • Insulin / metabolism
  • Pregnancy
  • Rh-Hr Blood-Group System*


  • Electrolytes
  • Insulin
  • Rh-Hr Blood-Group System
  • Glucose