Mitotic DNA damage and replication checkpoints in yeast

Curr Opin Cell Biol. 1998 Dec;10(6):749-58. doi: 10.1016/s0955-0674(98)80118-x.


Studies of the genetics of G2/M checkpoints in budding and fission yeasts have produced many of the defining concepts of checkpoint biology. Recent progress in the biochemistry of the checkpoint gene products is adding a mechanistic understanding to our models and identifying the components of the normal cell cycle machinery that are targeted by checkpoints.

Publication types

  • Review

MeSH terms

  • DNA Damage*
  • DNA Replication*
  • G2 Phase / genetics
  • Gene Expression Regulation, Fungal
  • Genes, Fungal
  • Mitosis / genetics
  • Saccharomyces cerevisiae / cytology
  • Saccharomyces cerevisiae / genetics
  • Schizosaccharomyces / cytology
  • Schizosaccharomyces / genetics
  • Yeasts / cytology
  • Yeasts / genetics*