The self-renewing mechanism of stem cells in the germline

Curr Opin Cell Biol. 1998 Dec;10(6):687-93. doi: 10.1016/s0955-0674(98)80108-7.


Germline stem cells (GSCs) are a self-renewing population of germ cells that serve as the source of gametes in diverse organisms. Current research suggests that the self-renewing division of GSCs is controlled both by somatic signaling and by intracellular mechanisms such as differential gene expression, asymmetric cytoskeletal organization, and the cell cycle machinery. These findings provide a framework for the further study of GSCs and stem cell renewal in general.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Germ Cells / cytology*
  • Stem Cells / cytology*