Control of immune pathology by regulatory T cells

Curr Opin Immunol. 1998 Dec;10(6):649-55. doi: 10.1016/s0952-7915(98)80084-8.


There is now compelling evidence that immune responses for both foreign and self antigens are downregulated by T cells that are specialised for this function; these are known as regulatory T (T reg) cells. This review describes progress in the characterisation of the T reg cells that mediate both mucosal tolerance and tolerance to self antigens. The recent work on the antigen specificity, generation and mode of action of T reg cells is also reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • CD4-Positive T-Lymphocytes / immunology
  • Humans
  • Immunity, Mucosal
  • T-Lymphocytes / immunology*