The role of antigen-presenting cells in the regulation of allergen-specific T cell responses

Curr Opin Immunol. 1998 Dec;10(6):607-13. doi: 10.1016/s0952-7915(98)80077-0.


Allergic reactions in atopic patients follow from a generalized enhanced polarization of Th cells, predominantly imposed by factors derived from antigen-presenting cells from a pathogen-stressed tissue; these sample information not only on antigen structures but also on the nature of the stress. Antigen-presenting cells of atopic individuals show aberrant characteristics which, through a highly interactive communication network, play an active role in aberrant Th-cell polarization. This generalized bias may follow from intrinsic abnormalities of antigen-presenting cells and also from a low degree of cross-regulation by micro-organisms.

Publication types

  • Review

MeSH terms

  • Allergens / immunology*
  • Animals
  • Antigen-Presenting Cells / immunology*
  • Dogs
  • Humans
  • Interleukin-12 / immunology
  • Mycobacterium Infections / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology


  • Allergens
  • Interleukin-12