The role of MHC class II molecules in susceptibility and resistance to autoimmunity

Curr Opin Immunol. 1998 Dec;10(6):677-81. doi: 10.1016/s0952-7915(98)80088-5.


The mechanism by which particular MHC class II alleles mediate susceptibility to a given autoimmune disease is unknown. During the past year, reports have indicated that the effects of MHC class II alleles which protect against type I diabetes in the nonobese diabetic mouse strain may, in some cases, be due to negative selection of diabetogenic T cell receptors and, in other cases, to positive selection of other T cells with a suppressive action on the diabetic process. Progress towards understanding the mechanisms of susceptibility continues to lag.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • Diabetes Mellitus, Type 1 / immunology
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Mice


  • Histocompatibility Antigens Class I