Ginkgo biloba extract EGb761 reduces the development of amphetamine-induced behavioral sensitization: effects on hippocampal type II corticosteroid receptors

Brain Res. 1999 Feb 6;818(1):135-9. doi: 10.1016/s0006-8993(98)01151-2.


Pretreatment of rats with the extract of Ginkgo biloba termed EGb761 reduced the behavioral sensitization induced by successive D-amphetamine administrations (0.5 mg/kg) as estimated by increasing values of locomotor activity. EGb761 pretreatment also prevented the reduced density of [3H]dexamethasone binding sites in the dentate gyrus and the CA1 hippocampal regions of D-amphetamine treated animals. These observations suggest that EGb761, by reducing glucocorticoid levels, could modulate the activity of the neuronal systems involved in the expression of the behavioral sensitization.

MeSH terms

  • Amphetamine / antagonists & inhibitors*
  • Animals
  • Dentate Gyrus / drug effects
  • Flavonoids / pharmacology*
  • Ginkgo biloba*
  • Hippocampus / drug effects*
  • In Vitro Techniques
  • Male
  • Motor Activity / drug effects
  • Neuroprotective Agents / pharmacology*
  • Plant Extracts / pharmacology*
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar
  • Receptors, Steroid / drug effects


  • Flavonoids
  • Neuroprotective Agents
  • Plant Extracts
  • Receptors, Steroid
  • Ginkgo biloba extract
  • Amphetamine