Increased number of galanin-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats

Brain Res. 1999 Feb 6;818(1):160-3. doi: 10.1016/s0006-8993(98)01264-5.

Abstract

Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate food intake by acting within the paraventricular hypothalamic nucleus (PVN). In early postnatally overfed rats overweight and hyperinsulinemia were observed, accompanied by an increased number of galanin-positive neurons in the PVN at weaning. Our results might indicate malformation of hypothalamic galaninergic neurons due to neonatal overfeeding and hyperinsulinism, respectively, in rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Count
  • Feeding Behavior / physiology*
  • Galanin / analysis*
  • Hyperinsulinism / metabolism
  • Hyperinsulinism / pathology
  • Neurons / chemistry*
  • Neurons / cytology
  • Paraventricular Hypothalamic Nucleus / chemistry*
  • Paraventricular Hypothalamic Nucleus / cytology
  • Rats
  • Rats, Wistar
  • Weaning

Substances

  • Galanin