Role of retinoids in renal development: pathophysiological implication

Curr Opin Nephrol Hypertens. 1999 Jan;8(1):39-43. doi: 10.1097/00041552-199901000-00007.


Vitamin A closely modulates nephron endowment at birth. It is also required for the development of renal vasculature. Fetal vitamin A status may thus be responsible for most of the variations in nephron number found in the general population, and may play a major role in the intrauterine programming of chronic renal disease and hypertension.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Kidney / embryology*
  • Kidney / physiology*
  • Kidney Diseases / physiopathology
  • Retinoids*
  • Vitamin A / physiology*


  • Retinoids
  • Vitamin A