Nitric oxide synthase gene transfer to the vessel wall

Curr Opin Nephrol Hypertens. 1999 Jan;8(1):75-81. doi: 10.1097/00041552-199901000-00012.


A wide array of vascular disorders have been shown to benefit from gene therapy. Given the vasoprotective role that nitric oxide plays in the vasculature, it is understandable why gene therapy with the three different isoforms of nitric oxide synthase has been so successful. This review summarizes the current literature pertaining to nitric oxide synthase gene transfer to the vascular wall.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Vessels / physiology*
  • Gene Transfer Techniques*
  • Humans
  • Nitric Oxide Synthase / genetics*


  • Nitric Oxide Synthase