Glyoxalase I activity in human prostate cancer: a potential marker and importance in chemotherapy

J Urol. 1999 Feb;161(2):690-1.

Abstract

Purpose: To provide information on the activity of Gly-I in prostate cancer.

Materials and methods: We performed qualitative Gly-I assay on prostate tissues.

Results: Gly-I activity between prostate cancer and noncancerous specimens differed substantially and significantly, although such activity also varied somewhat among cancer specimens.

Conclusions: Gly-I activity is indeed higher in cancerous than in noncancerous specimens, suggesting that it may play a role in prostate cancer homeostasis and survival.

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Humans
  • Lactoylglutathione Lyase / metabolism*
  • Male
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / enzymology*

Substances

  • Biomarkers, Tumor
  • Lactoylglutathione Lyase