Molecular interactions on microarrays

Nat Genet. 1999 Jan;21(1 Suppl):5-9. doi: 10.1038/4429.


The structural features of nucleic acid probes tethered to a solid support and the molecular basis of their interaction with targets in solution have direct implication for the hybridization process. We discuss how arrays of oligonucleotides provide powerful tools to study the molecular basis of these interactions on a scale which is impossible using conventional analysis.

Publication types

  • Review

MeSH terms

  • Base Composition
  • Base Pairing / physiology*
  • Base Sequence
  • Binding Sites
  • DNA Ligases / metabolism
  • DNA-Directed DNA Polymerase / metabolism
  • Nucleic Acid Conformation
  • Oligonucleotide Array Sequence Analysis*
  • Oligonucleotide Probes / chemical synthesis
  • Oligonucleotide Probes / chemistry
  • Oligonucleotide Probes / metabolism*


  • Oligonucleotide Probes
  • DNA-Directed DNA Polymerase
  • DNA Ligases