Resequencing and mutational analysis using oligonucleotide microarrays

Nat Genet. 1999 Jan;21(1 Suppl):42-7. doi: 10.1038/4469.


Oligonucleotide microarray (DNA chip)-based hybridization analysis is a promising new technology which potentially allows rapid and cost-effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip-based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip-based assays.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Mutational Analysis / methods*
  • Genetic Variation
  • Genome
  • Humans
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Probes
  • Sensitivity and Specificity


  • Oligonucleotide Probes