Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo

Science. 1999 Jan 22;283(5401):534-7. doi: 10.1126/science.283.5401.534.

Abstract

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural stem cells were found to produce a variety of blood cell types including myeloid and lymphoid cells as well as early hematopoietic cells. Thus, neural stem cells appear to have a wider differentiation potential than previously thought.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Cells / cytology*
  • Blood Cells / immunology
  • Bone Marrow Cells / immunology
  • Cell Differentiation
  • Cells, Cultured
  • Colony-Forming Units Assay
  • Female
  • H-2 Antigens / analysis
  • Hematopoiesis
  • Hematopoietic Stem Cells / cytology*
  • Lac Operon
  • Lymphocytes / cytology
  • Lymphocytes / immunology
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Transgenic
  • Prosencephalon / cytology*
  • Prosencephalon / embryology
  • Spleen / cytology
  • Stem Cell Transplantation
  • Stem Cells / cytology*
  • Stem Cells / immunology

Substances

  • H-2 Antigens
  • H-2K(K) antigen
  • H-2Kb protein, mouse