Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii

R W Fuller; J W Blunt; J L Boswell; J H Cardellina 2nd; M R Boyd

doi:10.1021/np9801514

Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii

J Nat Prod. 1999 Jan;62(1):130-2. doi: 10.1021/np9801514.

Authors

R W Fuller¹, J W Blunt, J L Boswell, J H Cardellina 2nd, M R Boyd

Affiliation

¹ Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research and Development Center, Building 1052, Room 121, Frederick, MD 21702-1201, USA.

PMID: 9917299
DOI: 10.1021/np9801514

Abstract

The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F (1). The structure was solved by extensive NMR analyses and by acid-catalyzed conversion to 30-epi-cambogin (4). This is the first report of this compound type in the genus Allanblackia.

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / isolation & purification*
Anti-HIV Agents / pharmacology
Benzophenones / chemistry
Benzophenones / isolation & purification*
Benzophenones / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Plants / chemistry*
Spectrometry, Mass, Fast Atom Bombardment

Substances

Anti-HIV Agents
Benzophenones
guttiferone F